Adenosine
Adenosine acts via A1 adenosine receptors in the SA and AV node, which when stimulated open K+ channels causing hyperpolarisation and a reduction in Ca2+ current, with subsequent blockade of AV nodal conduction.
| Property | Action |
|---|---|
| Class | Naturally occurring purine nucleoside |
| Uses | SVT |
| Presentation | Colourless solution at 3mg.ml-1 |
| Route of Administration | IV |
| Dosing | 3mg/6mg/12mg in increasing doses |
| Metabolism | Rapidly deaminated in plasma. t1/2 < 10s |
| Resp | Bronchospasm, ↑ RR and VT |
| CVS | ↓↓ AV nodal conduction, may cause AF/lutter |
| Toxic Effects | Contraindicated in sick-sinus syndrome, 2nd/3rd degree AV block |
Interactions
| Interaction | Drug |
|---|---|
| Increased effect | Dipyridamole |
| Decreased effect | Methylxanthines, such as aminophylline and caffeine |
References
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.