Adenosine acts via A1 adenosine receptors in the SA and AV node, which when stimulated open K+ channels causing hyperpolarisation and a reduction in Ca2+ current, with subsequent blockade of AV nodal conduction.
|Class||Naturally occurring purine nucleoside|
|Presentation||Colourless solution at 3mg.ml-1|
|Route of Administration||IV|
|Dosing||3mg/6mg/12mg in increasing doses|
|Metabolism||Rapidly deaminated in plasma. t1/2 < 10s|
|Resp||Bronchospasm, ↑ RR and VT|
|CVS||↓↓ AV nodal conduction, may cause AF/lutter|
|Toxic Effects||Contraindicated in sick-sinus syndrome, 2nd/3rd degree AV block|
|Decreased effect||Methylxanthines, such as aminophylline and caffeine|
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.