Potassium Channel Activators

Potassium channel activators stimulate ATP sensitive K+ channels, causing an increase in intracellular cGMP and subsequent relaxation of smooth muscle in the:

  • Heart
  • Venous capacitance vessels
  • Arterioles
Property Nicorandil
Uses HTN, angina, CHF
Route of Administration PO
Dosing 10-30mg BD
Absorption 80% PO bioavailability
Distribution Negligible protein binding
Metabolism Hepatic denitration
Elimination Renal elimination of active drug and metabolites
CVS ↓ Preload, ↓ afterload, ↓ BP, ↑ coronary flow
CNS Headache, improves with ongoing use
Haeme Inhibition of platelet aggregation


  1. Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.
Last updated 2017-09-22

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