Angiotensin Receptor Blockers

Angiotensin receptor antagonists are very similar to ACE inhibitors, except:

  • Bradykinin does not accumulate as it is still broken down by ACE
    Therefore there is no cough and patient compliance is improved.
  • The AT1 receptor in cardiac tissue is more comprehensively blocked which may improve cardiac outcomes
  • The AT2 receptor is not blocked, which may also improve cardiac outcomes


  1. Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.
Last updated 2017-07-27

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