Lincosamides
Inhibit protein synthesis by disrupting the 50S ribosomal subunit. May be bacteriostatic or bacteriocidal, depending on the concentration and the particular organism.
| Property | Clindamycin |
|---|---|
| Spectrum of Activity | Gram positive cocci, anaerobes. Little action against gram negative aerobes. Also active against some protozoa, such as P. falciparum. |
| Route of Administration | PO/IV |
| Dosing | 150-300mg Q6H |
| Absorption | 90% PO bioavailability |
| Distribution | Excellent bony penetration |
| Metabolism | Hepatic to active and inactive metabolites |
| Elimination | Renal elimination of all metabolites |
| MSK | May cause neuromuscular blockade in overdose |
| GIT | Reasonable incidence of GIT upset, with fatal pseudomembranous colitis reported. Deranged LFTs |
| Immune | Atopy, eosinophilia, DRESS |
References
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.
- Lexicomp. Clindamycin (systemic): Drug Information. In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2017.