Sotalol
The D-isomer of sotalol is a class III antiarrhythmic, whilst the L-isomer also has class II activity.
| Property | Action |
|---|---|
| Class | Class III antiarrhythmic |
| Uses | Tachyarrhythmia prophylaxis |
| Presentation | Solution at 10mg.ml-1 and tablets |
| Isomerism | Racemic mixture |
| Route of Administration | PO/IV |
| Dosing | PO: 40-160mg BD IV: 50-100mg over 20 minutes |
| Absorption | >90% bioavailability |
| Distribution | No protein binding |
| Metabolism | Not metabolised |
| Elimination | Excreted unchanged in urine |
| Resp | Bronchospasm |
| CVS | Torsades (< 2%) - more common with high doses, long QT, and electrolyte imbalances |
| CNS | Masking symptoms of hypoglycaemia |
| GU | Sexual dysfunction |
References
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.