Competitive antagonist and inverse agonist of the benzodiazepine receptor.

Property Action
Class Imidazo-benzodiazepine
Uses Reversal of BZD
Route of Administration IV
Dosing 0.1mg boluses up to 2mg
Onset Within 2 minutes
Distribution Moderate lipid solubility, 50% protein bound. t1/2β < 1 hour - may require infusion.
Metabolism Hepatic to inactive metabolites
Elimination Renal of metabolites
CNS May precipitate seizures or BDZ withdrawal due to inverse agonist effect


  1. Petkov V. Essential Pharmacology For The ANZCA Primary Examination. Vesselin Petkov. 2012.
Last updated 2017-09-17

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