Flumazenil

Competitive antagonist and inverse agonist of the benzodiazepine receptor.

Property Action
Class Imidazo-benzodiazepine
Uses Reversal of BZD
Route of Administration IV
Dosing 0.1mg boluses up to 2mg
Onset Within 2 minutes
Distribution Moderate lipid solubility, 50% protein bound. t1/2β < 1 hour - may require infusion.
Metabolism Hepatic to inactive metabolites
Elimination Renal of metabolites
CNS May precipitate seizures or BDZ withdrawal due to inverse agonist effect
GIT N/V

References

  1. Petkov V. Essential Pharmacology For The ANZCA Primary Examination. Vesselin Petkov. 2012.
Last updated 2017-09-17

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