2021A Question 4

Describe the factors that affect afterload for each of the right and left ventricles.

Examiner Report

54.6% of candidates achieved a pass in this question.

The major domains assessed in this question were:

• The differences between the left and right ventricles
• Extrinsic determinants of afterload as described by the Hagen-Poiseuille law
• Intrinsic determinants of afterload related to the Law of Laplace.

Typically answers that attempted to answer the questions “why?” and “how?” scored significantly better than those that presented simple lists. Credit was given for answers that demonstrated a better understanding of the factors and were able to integrate them into clinical examples, such as the effect of cardiac dilatation, ventricular hypertrophy and positive pressure ventilation. There were some excellent answers that illustrated in depth explanation of mechanisms and focused on factors that had opposite effects on each ventricle, highlighting the difference in afterload between the left and right side of the heart.

Common problems were:

• Incorrect recall of both the Hagen-Poiseuille law and the Law of Laplace
• Discussion of intrinsic factors (Laplace) without discussion of extrinsic factors (Hagen-Poiseuille) and vice versa
• Few candidates articulated that the radius is the most important determinant of resistance due to it’s fourth power

Structure:

• Introduction
• Determinants
• SVR
• PVR

Introduction

Factor Properties
Definition

- Sum of the factors contributing to total ventricular wall tension during systolic ejection

- Determined primarily by vascular resistance in health

Equations -
-
-
Left vs Right

- SVR is high (9-20 Wood units)

- High pressure circuit facilitates selective distribution

- Flow distribution determined by metabolic activity and SNS

- PVR is low (0.25-2 Wood units)

- Low pressure circuit minimizes transudation, preserves gas exchange

- Flow distribution determined mostly by gravity and HPV

- Many factors cause differential effects:

- ↑ Temp, ↓ O2, ↑ CO2, ↓ pH, ↑ histamine, ↑ bradykinin (↓ SVR, ↑ PVR)

- ↑↑ SVR → Thick-walled LV copes well

- ↑↑ PVR → Thin-walled RV copes poorly

Determinants

Factor Mechanism
Cardiac

Inflow tract:

- AV valve regurgitation (MR, TR) → ↓ AL

Ventricle:

- ↑ Wall thickness (e.g. AS, PHTN) → ↓ Load on individual fibres

- ↑ Cavity radius (e.g. Cardiomyopathy) → ↑ AL

Outflow tract:

- ↓ Radius (AS, PS, HCM) → ↑ AL

Vascular

- Resistance: See SVR and PVR

- Factors increasing resistance:

- ↓ Radius (power 4, hence most important factor)

- ↑ Viscosity (↑ Hct, ↓ temp, ↓ flow rate)

- ↑ Length (rarely important)

- Compliance: E.g. Atherosclerosis → ↓ Windkessel effect → ↑ AL

Thoracic

- Intrathoracic pressure: E.g. IPPV →

- ↓ LV afterload (↓ transmural pressure)

- ↑ RV afterload (↑ SVR)

SVR

Factor Mechanism
Physical

External compression → ↓ R

- Intra-abdominal pressure: E.g. Pneumoperitoneum

- Cross-clamp or tourniquet

Metabolic

Hyperactivity → ↑ R

- ↑ Temp

- ↓ O2

- ↑ CO2

- ↓ PH

- ↑ Lactate

Examples:

- Exercise (muscle)

- Pregnancy (uterus/placenta)

- Simple obesity

- Sepsis

Autonomic

Mechanisms:

- Neural NAd → Α1 →↓ r

- Hormonal Ad → Β2 → ↑ R

Examples:

- Pain

- Anxiety

- Exercise (↓ r in gut, skin, ↑ r in muscle)

Local

- Dilators: E.g. Histamine, bradykinin, NO

- Constrictors: E.g. TXA2, 5HT

PVR

Physical Factors

Physical Factor Mechanism
Blood pressure

- ↑ PAP or ↑ PVP → ↑ Radius

- Recruitment of collapsed vessels (West zone 1

- Distension of patent vessels (West zones 2, 3)

Alveolar pressure

- IPPV, PEEP → ↑ Alveolar pressure → Vessel collapse

- ↑ West Zone 1: Where PA > Pa > Pv

- ↓ Total vascular surface area

Relative lung volume

- ↓ Volume → ↓ Radial traction → Compress extra-alveolar vessels

- ↑ Volume → Alveolar distension → Compress alveolar vessels

- PVR lowest at FRC

Metabolic Factors

Metabolic Factor Mechanism
O2

Hypoxic pulmonary vasoconstriction (HPV)

-

- Serves to improve local V/Q matching

CO2 ↑ CO2 → ↓ R
pH ↓ PH → ↓ R
Temp ↓ T → ↓ R

Autonomic Factors

Autonomic Factor Mechanism
SNS

- Neural NAd → Α1 → ↓ R

- Hormonal Ad → Β2→ ↑ R ACh → ↑ R

PSNS ACh → ↑ NO release → ↑ R

Local Factors

Local Factor Mechanism
Dilators

- NO: ↑ cGMP → Activate MLCP, ↓ Ca2+ influx, ↑ K+ efflux

- PGI2

Constrictors e.g. ET, TXA2, 5HT, histamine, bradykinin

Last updated 2022-01-19