Sugammadex
| Property | Sugammadex |
|---|---|
| Class | Gamma cyclodextrin. |
| Uses | Reversal of neuromuscular block induced by rocuronium and vecuronium. |
| Presentation | Clear colourless solution at 100mg.ml-1. |
| Pharmaceutics | Store below 30°C. |
| Route of Administration | IV only. |
| Dosing | 2mg.kg-1 if ToF > 2. 4mg.kg-1 if PTC > 2. 16mg.kg-1 for reversal following RSI dose. |
| Distribution | VD of 11-14L.kg-1. |
| Metabolism | Not metabolised. |
| Elimination | Renal elimination of active drug and complex. |
| Mechanism of Action | Forms a complex with rocuronium and vecuronium, causing reversal of neuromuscular blockade. |
| CVS | Rarely may precipitate bradycardia - can result in cardiac arrest. |
| Immune | Anaphylaxis. |
| Other | Interacts with OCP - treat as missed pill Shortened duration of rocuronium and vecuronium when used within 24 hours of sugammadex administration. Onset is delayed up to 5 minutes, and duration shortened by 10-15 minutes. This period may be extended in renal failure. |