Property Sugammadex
Class Gamma cyclodextrin.
Uses Reversal of neuromuscular block induced by rocuronium and vecuronium.
Presentation Clear colourless solution at
Pharmaceutics Store below 30°C.
Route of Administration IV only.
Dosing if ToF > 2. if PTC > 2. for reversal following RSI dose.
Distribution VD of
Metabolism Not metabolised.
Elimination Renal elimination of active drug and complex.
Mechanism of Action Forms a complex with rocuronium and vecuronium, causing reversal of neuromuscular blockade.
CVS Rarely may precipitate bradycardia - can result in cardiac arrest.
Immune Anaphylaxis.
Other Interacts with OCP - treat as missed pill
Shortened duration of rocuronium and vecuronium when used within 24 hours of sugammadex administration. Onset is delayed up to 5 minutes, and duration shortened by 10-15 minutes. This period may be extended in renal failure.


  1. Sugammadex Full Prescribing Information. FDA.
Last updated 2019-07-20

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